Reactivations Associated with the Use of 5-MeO-DMT Among Spanish-Speaking Individuals: Prevalence, Predictors, and Emotional Valence.
J Psychoactive Drugs October 23, 2025 A.M. Ortiz Bernal, C.L. Raison, R.L. Lancelotta et al.
Among Spanish-speaking individuals who have used 5-MeO-DMT, spontaneous re-experiences of the substance's effects—often called reactivations—are relatively common, typically non-distressing, and often positively valenced. The study reports the prevalence of these reactivations and identifies predictors such as higher doses and greater emotional impact during the original experience. Most users describe these residual effects as neutral or positive, contributing to lasting well-being rather than distress.