25X-NBOMe compounds - chemistry, pharmacology and toxicology. A comprehensive review.
Critical reviews in toxicology January 1, 2023 Monika Herian, Paweł Świt 9 citations
Hallucinogenic therapies show promise for neuropsychiatric disorders, but new psychoactive substances (NPS) like 25X-NBOMes—synthetic compounds with strong hallucinogenic properties—pose high toxicity risks. 25X-NBOMes bind strongly to serotonin, dopamine, adrenergic, and histamine receptors, causing severe intoxications and deaths. In humans, common side effects include tachycardia, anxiety, hypertension, and seizures. Preclinical studies confirm developmental impairments, cytotoxicity, cardiovascular toxicity, and behavioral changes. Their complex metabolism, involving many pathways, may explain the high toxicity. This review summarizes current knowledge about 25X-NBOMes, focusing on toxicity.