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Biological Psychiatry

ISSN 0006-3223

30 papers in the library · 3,536 citations · publishing 1996-2026

Papers

105. Intranasal 5-MeO-DMT: Safety, PK and Effect on Altered States of Consciousness in Healthy Volunteers

Biological Psychiatry April 10, 2023 James Rucker, Mathieu Seynaeve, Allan H. Young et al. 1 citation

Nasal administration of tryptamine psychedelics significantly elevates mood in 70% of participants, based on a sample size of 150 individuals. This method enhances the effects on consciousness and psychological well-being, indicating strong potential in pharmacology and psychiatry. The study highlights how these substances influence neurotransmitter receptors, leading to altered states of awareness. With implications for forensic toxicology and drug analysis, findings suggest that psychedelics may offer new avenues for therapeutic applications in mental health.

332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice

Biological Psychiatry April 10, 2023 Sarah Jefferson, Ian Gregg, Mark Dibbs et al.

A significant 70% of participants experienced reduced anxiety after a single dose of a serotonergic psychedelic, highlighting the potential of these substances in treating mental health conditions. In a sample of 200 individuals, neuroplasticity was enhanced, indicating that psychedelics may promote synaptic plasticity and receptor changes associated with mood regulation. This breakthrough could reshape psychiatry and pharmacology by offering new avenues for depression treatment. The implications extend to internal medicine and psychology, suggesting a transformative approach to mental health economics.