A month-long remote randomized controlled trial compared three daily five-minute breathwork exercises—cyclic sighing (prolonged exhalations), box breathing (equal inhale, hold, exhale), and cyclic hyperventilation with retention (longer inhales, shorter exhales)—against mindfulness meditation. Cyclic sighing produced greater improvements in mood and greater reductions in respiratory rate than mindfulness meditation. The findings suggest that brief, exhale-focused breathwork may be an effective stress management tool.
A single 25 mg dose of psilocybin produces a short-term antidepressant effect in people with medication-resistant depression. Unanswered questions remain about whether drug blood levels can guide dosing, how the psychedelic experience relates to the antidepressant benefit, and whether psilocybin carries a risk of suicide.
Lysergic acid diethylamide (LSD) may alleviate depression by altering white matter microstructure in the brain, potentially reflecting enhanced neuroplasticity. In a clinical trial of 61 patients with major depressive disorder, those receiving moderate-to-high doses (100 μg then 200 μg) showed increased fractional anisotropy in several white matter tracts, including the internal and external capsule, sagittal stratum, and fornix/stria terminalis. These microstructural changes correlated with improvements in depressive symptoms measured at 2, 6, and 12 weeks. The findings suggest that LSD-induced white matter changes are linked to antidepressant effects.