Medical Toxicology: Diagnosis and Treatment of Human Poisoning.
Annals of Internal Medicine March 1, 1988 957 citations
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Annals of Internal Medicine
ISSN 0003-4819
6 papers in the library · 1,327 citations · publishing 1941-2025
Papers
THE MORPHINE ABSTINENCE SYNDROME, ITS NATURE AND TREATMENT
Annals of Internal Medicine November 1, 1941 C. K. Himmelsbach 147 citations
Drug addiction is a condition where an individual loses self-control over continued drug use, making separation from the drug essential for treatment. Tolerance, habituation, and physical dependence vary among addictions to opiates, marijuana, barbiturates, alcohol, tobacco, caffeine, and other drugs. Tolerance refers to reduced responsiveness to a drug's effects.
Cardiovascular Effects of 3,4-Methylenedioxymethamphetamine: A Double-Blind, Placebo-Controlled Trial
Annals of Internal Medicine December 19, 2000 Steven J. Lester, Matthew J. Baggott, Susette Welm et al. 140 citations
A modest oral dose of MDMA (1.5 mg/kg) increases heart rate by 28 beats per minute, systolic blood pressure by 25 mm Hg, diastolic blood pressure by 7 mm Hg, and cardiac output by 2 L per minute in healthy adults who have used the drug before. These cardiovascular effects are similar to those of the heart stimulant dobutamine at doses of 20 to 40 micrograms per kilogram per minute. Unlike dobutamine, MDMA shows no measurable effect on the heart's pumping strength (inotropism). The findings suggest that even moderate MDMA use raises myocardial oxygen demand without enhancing the heart's contractile force.
The Paradox of Phencyclidine (PCP) Abuse
Annals of Internal Medicine March 1, 1979 R. C. Stillman, Robert C. Petersen 38 citations
Phencyclidine (PCP, known as 'angel dust') is a dangerous drug with acute and chronic risks. High accidental doses can cause severe or fatal medical complications, acute and recurrent psychoses, suicidal depressions, and unpredictable violence. Chronic use leads to aggressiveness, psychological dependence, memory loss, and physiological dependence. Its use is widespread, and among abused drugs it has no current rivals for its disturbing effects.
The Rise of Psilocybin Use in the United States: A Multisource Observational Study
Annals of Internal Medicine April 21, 2025 Karilynn Rockhill, Joshua C. Black, Michael S. Ladka et al. 29 citations
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LSD-LIKE DELIRIUM FOLLOWING INGESTION OF A SMALL AMOUNT OF ITS BROM ANALOG (BOL-148)
Annals of Internal Medicine May 1, 1958 Nicholas T. Richards, Latasha Chapman, H Goodell et al. 16 citations
Ingestion of a small amount of 2-bromo-d-lysergic acid diethylamide (BOL-148), a bromine analog of LSD, produced a delirium resembling that caused by LSD itself. BOL-148 was previously thought to block the psychological effects of LSD, but the case reported here demonstrates that it can also induce an LSD-like mental disturbance. The compound is known to have an anti-serotonin effect, similar to LSD, which may underlie its psychoactive properties.