Multiple sclerosis and related disorders
July 1, 2025
Darina Slezáková, Louise Mária Adamová, Peter Marček et al.
3 citations
A 12-week program combining cold exposure, controlled breathing, and mindfulness (the Wim Hof Method) improved cognition, fatigue, anxiety, and depression in people with multiple sclerosis. Compared to a control group receiving no intervention, the 12 participants in the Wim Hof group showed significantly greater gains on tests of processing speed and executive function, as well as reductions in fatigue, anxiety, and depression. The findings suggest the method may serve as a complementary non-pharmacological treatment for neuropsychiatric symptoms of multiple sclerosis.
Multiple sclerosis and related disorders
November 1, 2025
Yang Yang, Xinyi Duan, Jing Wang et al.
1 citation
Ofatumumab, a fully humanized anti-CD20 antibody, reduced disease activity and disability progression in Chinese patients with relapsing multiple sclerosis. Among 38 treatment-naïve patients, the annualized relapse rate fell from 0.27 to 0.05, and the median disability score dropped from 2.50 to 2.00 after 12 months. Among 59 patients who switched from oral therapies (teriflunomide, siponimod, fingolimod, dimethyl fumarate) due to disease progression, relapse, or MRI activity, the relapse rate decreased from 0.45 to 0.08 and disability scores improved from 2.00 to 1.00. No new MRI lesions, relapses, or serious adverse events occurred in either group.
Multiple sclerosis and related disorders
December 1, 2024
Training in neuroinflammatory disorders like multiple sclerosis is a fast-growing area of neurology, but pressures on specialty training and an expanding curriculum make it hard to prepare trainees for subspecialist careers. A structured questionnaire of UK neurology trainees revealed significant gaps: insufficient training opportunities, lack of mentorship, and concerns about managing complex treatments. These findings led to structured action points, including early subspecialty exposure, enhanced mentorship, and equal access to training regardless of location. The results underscore the need for curriculum development combining early support with dedicated fellowships to sustain the neuroinflammation subspecialty and meet growing demand for expertise in MS and related conditions.