Journal of Pain Research
March 1, 2024
Christopher L. Robinson, Alexandra Fonseca, Efemena Diejomaoh et al.
32 citations
Psychedelics may help reduce pain symptoms associated with various chronic pain conditions, but more rigorous research—specifically randomized, double-blind, placebo-controlled trials—is required to determine their effectiveness for chronic, non-cancer pain.
Journal of Pain Research
June 1, 2022
Sandra J Drozdz, Akash Goel, Matthew W Mcgarr et al.
2 citations
Ketamine-assisted psychotherapy (KAP) can, in specific circumstances, initiate and prolong clinically significant reductions in pain, anxiety, and depressive symptoms, while encouraging rapport and treatment engagement, and promoting abstinence in patients addicted to other substances. A systematic review of seventeen articles including 603 participants found that combining ketamine with psychotherapy, provided before, during, and after ketamine sessions, can maximize and prolong benefits despite much variance in how KAP is applied. Additional large-scale randomized controlled trials are warranted to understand better the mutually influential relationships between psychotherapy and ketamine in optimizing responsiveness and sustaining long-term benefits in patients with chronic pain.