Serotonin 5- Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases
Cardiovascular Psychiatry and Neurology October 13, 2009 Charles D. Nichols 43 citations
High comorbidity between neuropsychiatric and cardiovascular disorders may be partly explained by the serotonin system, specifically the 5-HT2A receptor. In the brain, this receptor modulates cognition, working memory, and is implicated in schizophrenia and the effects of hallucinogenic drugs. In the periphery, it contributes to vasoconstriction, hypertension, and inflammatory processes that can lead to atherosclerosis. The hypothesis suggests this receptor is a common contributing factor underlying aspects of the comorbidity.