ISSN 2184-4860
4 papers in the library · 4 citations · publishing 2022-2025
RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia April 6, 2022 Cesar Filho, Joana Fernandes, Andreia Machado Brito-Da-Costa et al. 2 citations
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RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia April 6, 2022 2 citations
No Summary
RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia February 7, 2025 Hugo Santos, Catarina Redinha, Catarina Pereira et al.
Chronic pain affects a large portion of the global population, and current treatments are often insufficient, prompting exploration of psychedelics. This scoping review mapped the literature on psychedelics for chronic pain, analyzing 15 publications. Both macrodoses and microdoses of classic psychedelics showed therapeutic potential, with several studies reporting improvements in pain perception. However, significant limitations include methodological variability, lack of dosage and protocol specificity, and absence of studies combining psychedelics with other recommended therapies. Some adverse side effects were noted. The authors conclude that psychedelics are promising but research is limited and should be approached cautiously, recommending primary efficacy studies before further reviews.
RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia January 1, 2025 Andreia Machado Brito Da Costa, Ricardo Jorge Dinis-Oliveira, Áurea Madureira-Carvalho et al.
Psychedelic compounds such as LSD, psilocin, psilocybin, 5-MeO-DMT, and mescaline show distinct neurotoxicity profiles in human neuroblastoma cells. LSD was the most cytotoxic, with EC50 values of 0.23 mM (MTT) and 0.57 mM (NR), while psilocin showed moderate toxicity (EC50 0.42 mM MTT, 0.69 mM NR). Psilocybin did not reach an EC50 within the tested range, indicating minimal toxicity. 5-MeO-DMT and mescaline affected cell viability only at higher concentrations (EC50 1.17–1.69 mM). Pre-treatment with any of these compounds did not significantly protect against glutamate-induced toxicity, suggesting limited neuroprotective potential in this model.