Revista Brasileira de Farmacognosia
September 15, 2011
Carolina Dizioli Rodrigues de Oliveira, Camila Queiroz Moreira, Helenice de Souza Spinosa et al.
25 citations
Rats exposed to ayahuasca from the 6th day of pregnancy through the 10th day of lactation showed no changes in physical or reflex development. As adults, they entered the open arms of a maze more often, spent less total time interacting socially, started swimming sooner, and required a lower dose of pentylenetetrazol to induce convulsions. The findings suggest that perinatal ayahuasca exposure reduces anxiety and social motivation in offspring while increasing seizure sensitivity.
Revista Brasileira de Farmacognosia
March 9, 2017
Alana de Fátima Andrade Santos, Ana Luiza Sarkis Vieira, Aline Pic‐taylor et al.
19 citations
Chronic ayahuasca exposure in male Wistar rats reduced food intake and body weight gain at higher doses and increased relative brain and stomach weight at the highest dose. Total serum testosterone increased and sperm transit time and reserves in the epididymis caudae decreased at four times the ritualistic dose, but not at the highest dose. No effects were observed on sperm motility, morphology, total count, daily production, or testis and epididymis histology. The no-observed-adverse-effect-level for chronic and reproductive effects was two times the ritualistic dose, corresponding to 0.62 mg/kg bw DMT, 6.6 mg/kg bw harmine, and 0.52 mg/kg bw harmaline. A non-monotonic dose-response suggests potential toxicity at intermediate doses.
Revista Brasileira de Farmacognosia
July 1, 2010
Thiago Berti Kirsten, Maria Martha Bernardi
7 citations
An aqueous extract of the hallucinogenic mushroom Psilocybe cubensis, which contains the serotonin receptor agonists psilocybin and psilocin, produced specific behavioral changes in mice. Compared to a control group, treated animals showed increased gnawing, wet-dog shakes, and decreased locomotion and rearing frequencies 29–38 minutes after injection. Female mice were more sensitive to the extract than males. The results suggest the extract interferes with central serotonergic and dopaminergic systems, and the observational methods used were effective for evaluating its acute toxic effects.