Archives of Biological Sciences
December 5, 2018
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
7 citations
A single oral dose of ibogaine (1 or 20 mg/kg body weight) in rats did not alter the activities of superoxide dismutases, catalase, glutathione peroxidase, glutathione reductase, or glutathione-S-transferase in the liver or erythrocytes at 6 or 24 hours after administration. However, hepatic xanthine oxidase activity increased in rats receiving 20 mg/kg, indicating faster adenosine turnover. TBARS concentration rose in the 1 mg/kg group after 24 hours, suggesting mild oxidative stress. Histological examination revealed glycogenolytic activity in hepatocytes, peaking at 24 hours in the higher-dose group. Ibogaine influenced hepatic redox homeostasis but not enough to remodel antioxidant enzyme activities within the timeframe studied.
Archives of Biological Sciences
January 1, 2019
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
4 citations
A single oral dose of ibogaine (1 or 20 mg/kg body weight) in rats altered kidney antioxidant enzyme activities and caused mild morphological changes without affecting overall kidney function. The lower dose increased superoxide dismutase 1 activity and decreased glutathione reductase activity at 6 and 24 hours; the higher dose also decreased glutathione reductase activity, indicating disrupted redox balance. After 24 hours, moderate structural changes in kidney tissue were observed, but urinalyses showed no impairment of kidney function. The authors advise monitoring kidney function during and after ibogaine use in humans.
Archives of Biological Sciences
December 16, 2025
Hamida Youcef Islam, Chouba Ibtissem, Habbachi Wafa
An ethanolic extract of Matricaria chamomilla (EEC) counteracted harmine-induced anxiety- and depression-like behaviors in rats. In a forced swimming stress protocol, groups of Wistar rats received either harmine alone (40 mg/kg), EEC alone (200 or 500 mg/kg), or harmine combined with EEC. EEC ameliorated harmine-induced reductions in locomotor activity, exploration, and memory performance. It also lowered circulating adrenocorticotropic hormone (ACTH) levels and restored antioxidant enzyme activity, reducing brain oxidative-stress markers such as malondialdehyde. The findings suggest that oral EEC supplementation may enhance exploratory behavior and modulate oxidative stress, indicating a potential prophylactic effect against depressive states.