Pharmacology and Neurotoxicity of 5-MeO-DIPT
Handbook of Neurotoxicity January 1, 2021 Krystyna Gołembiowska
The psychedelic drug 5-MeO-DIPT (street name 'foxy') acts as a serotonin transporter inhibitor and agonist at serotonin receptors, producing hallucinogenic effects and increasing release of dopamine, serotonin, and glutamate in rat brain regions. In cell lines, it shows potent cytotoxicity. Repeated intermittent doses during adolescence in rats reduced the response to a subsequent challenge dose in some brain regions and caused oxidative DNA damage in the cortex. Exposed rats showed stronger neurotransmitter responses to MDMA and performed worse on cognitive tasks, with impairments in long-term memory and cognitive flexibility, suggesting that adolescent exposure may lead to neurological problems in adulthood.