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Carotid Artery Occlusion Following Ingestion of LSD

Abraham Lieberman, William Bloom, Pulla S. Kishore, Joseph P. Lin

Stroke March 1, 1974 DOI: 10.1161/01.str.5.2.213 via OpenAlex

Summary

AI-generated from the abstract

A 20-year-old white woman developed left-sided paralysis after ingesting LSD. Initial angiography showed severe narrowing of the internal carotid artery at the siphon, which within days progressed to complete blockage at that site. The authors suggest that LSD, an amine derivative of ergot alkaloids, caused the initial blood vessel constriction and subsequent occlusion.

Study at a glance

Characteristics Case study Case report Peer reviewed
Sample size 1
Population 20-year-old white woman
Intervention LSD
Keywords Ingestion Vasoconstriction Occlusion Angiography Cardiology
Citations 37
Key finding LSD ingestion was associated with marked constriction of the internal carotid artery that progressed to occlusion, leading to hemiplegia.

Abstract

A 20-year-old white woman developed a left hemiplegia following the ingestion of LSD. Initial angiography revealed marked constriction of the internal carotid artery at the level of the siphon which, in a few days, was converted to occlusion of the carotid artery at that level. It is suggested that LSD, an amine derivative of the ergot alkaloids, was responsible for the initial vasoconstriction and subsequent occlusion.

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