Chromosome Abnormality in Offspring of LSD User
JAMA February 9, 1970 DOI: 10.1001/jama.1970.03170060051010 via OpenAlex
Summary
AI-generated from the abstractA newborn girl with congenital abnormalities consistent with D1-trisomy was found to have trisomy 13 accompanied by a D/D translocation. Her parents had used lysergic acid diethylamide (LSD) before conception but not during the pregnancy. The authors suggest that LSD may have damaged maternal germ cells prior to fertilization, leading to chromosomal rearrangement. Fertilization involving a gamete with an unbalanced chromosome complement may directly cause the chromosomal aberration observed in the offspring.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Newborn girl with trisomy 13 |
| Topics | LSD |
| Keywords | Offspring Trisomy Medicine Chromosomal translocation Pregnancy |
| Citations | 33 |
| Key finding | Lysergic acid diethylamide use prior to conception may have induced chromosomal rearrangement leading to trisomy 13 in the offspring. |
Abstract
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement. Fertilization of a gamete with unbalanced chromosome complement may be the direct cause of the chromosomal aberration in the offspring.