Multiple Systemic and Ocular Malformations Associated With Maternal LSD Usage
Archives of Ophthalmology October 1, 1974 DOI: 10.1001/archopht.1974.01010010311008 via OpenAlex
Summary
AI-generated from the abstractA male infant was born with severe malformations including anencephaly, absence of the left arm, cleft lip and palate, fused fingers, and eye defects such as coloboma, cataract, and corneal opacity. The mother had used LSD before and during pregnancy. The limb amputation deformities are the primary findings. These changes are sufficiently specific to suggest a correlation with other reported cases where a higher than expected incidence of such deformities occurs after maternal LSD use. This is only the second recorded case of lens abnormalities associated with maternal LSD ingestion.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Male infant exposed to LSD in utero |
| Topics | LSD |
| Keywords | Medicine Coloboma Syndactyly Anencephaly Pregnancy |
| Citations | 27 |
| Key finding | Limb amputation deformities and lens abnormalities in an infant are associated with maternal LSD ingestion during pregnancy. |
Abstract
A boy was born with multiple malformations including anencephaly with ectopic placenta, absent left arm, cleft lip and palate, syndactyly, coloboma of the iris, cataract, and corneal opacity with vascularization. The mother had used lysergic acid diethylamide (LSD) before and during pregnancy. The limb amputation deformities are the primary findings in this case. These changes are sufficiently specific to suggest a correlation with other reported cases in which a higher than expected incidence of such deformities are observed in infants following maternal ingestion of the drug. This is only the second recorded case of lens abnormalities associated with maternal LSD ingestion.