Three patients developed persistent palinopsia (recurring or prolonged afterimages) after taking LSD. Clinicians should ask about past LSD use in anyone presenting with seemingly spontaneous, isolated palinopsia. Recognizing this syndrome could prevent unnecessary anxiety and excessive diagnostic testing.
A premature baby girl was born with severe eye malformations—small eyes (microphthalmos), cartilage inside the eye, cataract, persistent hyperplastic primary vitreous, and retinal dysplasia. The mother had taken LSD during the first three months of pregnancy. This is the third reported case linking maternal LSD use to eye defects in the baby. More cases are needed to confirm whether LSD actually causes these malformations.
A male infant was born with severe malformations including anencephaly, absence of the left arm, cleft lip and palate, fused fingers, and eye defects such as coloboma, cataract, and corneal opacity. The mother had used LSD before and during pregnancy. The limb amputation deformities are the primary findings. These changes are sufficiently specific to suggest a correlation with other reported cases where a higher than expected incidence of such deformities occurs after maternal LSD use. This is only the second recorded case of lens abnormalities associated with maternal LSD ingestion.