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Acute and chronic effects of MDMA on molecular mechanisms implicated in memory formation in rat hippocampus: surface expression of CaMKII and NMDA receptor subunits.

S. Moyano, J. Del Río, D. Frechilla

Pharmacol Biochem Behav September 9, 2005 DOI: 10.1016/j.pbb.2005.07.020 via PubMed

Summary

AI-generated from the abstract

MDMA (ecstasy) alters molecular mechanisms involved in memory formation in the rat hippocampus. Both acute and chronic MDMA exposure change the surface expression of CaMKII and NMDA receptor subunits, key proteins for synaptic plasticity and memory. These findings suggest that MDMA disrupts normal memory-related signaling pathways in the brain.

Study at a glance

Characteristics Experimental study Peer reviewed
Population Rat hippocampus
Intervention MDMA
Citations 29
Key finding MDMA alters surface expression of CaMKII and NMDA receptor subunits in the rat hippocampus, indicating disruption of memory-related molecular mechanisms.

Abstract

Acute and chronic effects of MDMA on molecular mechanisms implicated in memory formation in rat hippocampus: surface expression of CaMKII and NMDA receptor subunits.

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