Pharmacological modulation of anxiety-like behavior by flumazenil, midazolam, and ketamine in rats: Evidence from aversive ultrasonic vocalizations and elevated plus maze.
Marcela Unterspann, Chrysostomos Charalambous, Martin Votava, Ladislav Hess, Jiri Sliva, Marek Lapka
Pharmacol Biochem Behav May 25, 2026 DOI: 10.1016/j.pbb.2026.174216 via PubMed
Summary
AI-generated from the abstractFlumazenil, midazolam, and ketamine each modulate anxiety-like behavior in rats, as measured by aversive ultrasonic vocalizations and performance on the elevated plus maze. The study provides evidence that these pharmacological agents affect anxiety-related responses, with results indicating distinct effects depending on the drug and behavioral test. No specific numerical outcomes or sample sizes are reported in the abstract.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Flumazenil Midazolam Ketamine |
| Key finding | Flumazenil, midazolam, and ketamine modulate anxiety-like behavior in rats, as evidenced by changes in aversive ultrasonic vocalizations and elevated plus maze performance. |
Abstract
Pharmacological modulation of anxiety-like behavior by flumazenil, midazolam, and ketamine in rats: Evidence from aversive ultrasonic vocalizations and elevated plus maze.