Esketamine combined with a mindfulness-based intervention for individuals with alcohol problems.
Emily M Gent, Joshua W Bryan, Maisy A Cleary, Tegan I Clarke, Harry D Holmwood, Rania O Nassereddine, Chris Salway, Simon Depla, Sarah Statton, Joy Krecké, Celia Ja Morgan
Journal of psychopharmacology (Oxford, England) June 1, 2024 DOI: 10.1177/02698811241254834 via PubMed
Summary
AI-generated from the abstractA double-blind pilot study tested whether a single dose of esketamine, combined with two weeks of daily mindfulness-based intervention (MBI), enhances engagement in meditation and improves alcohol-related outcomes among 28 individuals with alcohol problems. Participants received either sublingual esketamine (115.1 mg) or a vitamin C placebo. Esketamine increased psychological engagement with daily MBI and produced transient decreases in alcohol cravings, along with greater mystical experiences and dissociative states compared to placebo. The findings suggest that esketamine may improve treatment outcomes when paired with mindfulness-based therapies by boosting engagement with meditative practice.
Study at a glance
| Characteristics | Double-blind pilot randomized controlled trial Pilot study Peer reviewed |
|---|---|
| Sample size | 28 |
| Population | Individuals with alcohol problems |
| Interventions | Esketamine hydrochloride (AWKN002: 115.1 mg) Vitamin C (placebo) |
| Dose | 115.1 mg |
| Duration | 2 weeks of daily MBI |
| Topics | Addiction Esketamine Meditation |
| Keywords | Engagement Ketamine-assisted therapy Mindfulness-based intervention |
| Citations | 20 |
| Key finding | Esketamine enhanced psychological engagement with daily mindfulness-based intervention and led to transient decreases in alcohol cravings compared to placebo. |
Abstract
Alcohol use disorder (AUD) is a major public health issue, posing harmful consequences for individuals and society. Recent advances in addiction research have highlighted the therapeutic potential of ketamine-assisted therapy for AUD. However, the exact mechanisms underlying its effectiveness remain unknown. This double-blind, pilot study aimed to investigate esketamine combined with mindfulness-based intervention (MBI) to examine whether esketamine enhances engagement in MBI for individuals with alcohol misuse problems and whether enhanced engagement has any impact on alcohol-related outcomes. In all, 28 individuals with alcohol problems were randomly assigned to receive sublingual esketamine hydrochloride (AWKN002: 115.1 mg) or vitamin C (placebo) in an oral thin film and took part in 2 weeks of daily MBI. Participants were assessed on various self-report measures, including mindfulness, engagement in MBI (physical and psychological), alcohol cravings and consumption. Esketamine enhanced psychological engagement with a daily MBI, compared to placebo, and led to transient decreases in alcohol cravings. Esketamine also resulted in significantly greater mystical experiences and dissociative states compared to placebo. The findings suggest that esketamine may improve treatment outcomes when combined with mindfulness-based therapies through its ability to increase engagement with meditative practice.