Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain.
T Yoshikawa, C Kunishima, K Yamada, T Nabeshima, H Shibuya, M Toru
Peptides January 1, 1994 DOI: 10.1016/0196-9781(94)90208-9 via PubMed
Summary
AI-generated from the abstractA single injection of methamphetamine or phencyclidine reduces cholecystokinin (CCK) mRNA in the posterior cortex and hippocampus of rat brains from 30 minutes to 48 hours after treatment, while no significant changes occur in the frontal cortex. The findings suggest that CCK gene expression responds differently to these psychoactive drugs across different cortical regions.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rat brains |
| Interventions | methamphetamine phencyclidine |
| Duration | 30 min to 48 h after injection |
| Key finding | Decreases in CCK mRNA were observed in the posterior cortex and hippocampus from 30 min to 48 h after drug treatment, with no significant changes in the frontal cortex. |
Abstract
The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.