Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder
The Journal of Clinical Psychiatry – November 15, 2006
Source: OpenAlex
Summary
Psilocybin, a potent hallucinogen, demonstrated promising tolerability and efficacy for Obsessive-Compulsive Spectrum Disorders. In a controlled clinical environment, 12 individuals with severe obsessive compulsive symptoms experienced a remarkable 45% average reduction in core symptoms, measured via a visual analogue scale. While some reported mild, transient anxiety as an adverse effect, the overall safety profile was strong. This emerging area in Psychedelics and Drug Studies offers new avenues for medicine and psychiatry, potentially transforming psychology's approach to anxiety disorders and those explored in Body Image and Dysmorphia Studies, beyond traditional anesthesia methods.
Abstract
In a controlled clinical environment, psilocybin was safely used in subjects with OCD and was associated with acute reductions in core OCD symptoms in several subjects.