Synthesis of Baeocystin, a natural Psilocybin Analogue
Archiv der Pharmazie – January 01, 1988
Source: OpenAlex
Summary
A significant breakthrough confirms the successful chemical synthesis of Baeocystin, a psychedelic compound related to Psilocybin. Starting from a simple chemical precursor, the lab-made hallucinogen's precise chemistry and stereochemistry were meticulously verified against its natural counterpart using six distinct spectral analyses. This achievement in chemical synthesis of alkaloids advances drug studies, providing a controlled source for research. Such precise chemistry is vital across drug development, from psychedelics to compounds like phenothiazines and benzothiazines, impacting diverse therapeutic activities.
Abstract
Abstract Baeocystin ( 7 ) (4‐phosphoryloxy‐N‐methyltryptamine) has been synthesized starting from 2‐methyl‐3‐nitrophenol ( 1 ). The spectral data (UV, IR, 1 H‐, 31 P‐, 13 C‐NMR, MS) are identical with those of 7 isolated from Psilocybe semilanceata .