Long-lasting analgesic effect of the psychedelic drug changa: A case report
Journal of Psychedelic Studies – February 12, 2019
Source: OpenAlex
Summary
Given that pain is often inadequately treated, a compelling case report (n=1) observed a long-lasting analgesic effect from changa, a psychedelic drug. This medicine combines N,N-dimethyltryptamine with *Peganum harmala* seeds, rich in β-carboline alkaloids. This unique pharmacology, influencing various neurotransmitter systems, suggests its potential as an analgesic. Such findings, emerging from Psychedelics and Drug Studies, offer preliminary evidence for novel pain management strategies, expanding beyond areas like Cannabis and Cannabinoid Research.
Abstract
Pain is the most prevalent symptom of a health condition, and it is inappropriately treated in many cases. Here, we present a case report in which we observe a long-lasting analgesic effect produced by changa, a psychedelic drug that contains the psychoactive N,N-dimethyltryptamine and ground seeds of Peganum harmala, which are rich in β-carbolines. We describe the case and offer a brief review of supportive findings. A long-lasting analgesic effect after the use of changa was reported. Possible analgesic mechanisms are discussed. We suggest that both pharmacological and non-pharmacological factors could be involved. These findings offer preliminary evidence of the analgesic effect of changa, but due to its complex pharmacological actions, involving many neurotransmitter systems, further research is needed in order to establish the specific mechanisms at work.