LSD "Mainlining"
JAMA – June 19, 1967
Source: OpenAlex
Summary
LSD, commonly taken in doses ranging from 25μg to 150μg, is remarkably safe compared to its potent effects, with no reported deaths directly linked to its use. Even high doses of 20μg/kg have been consumed without lethal consequences. While LSD can induce profound hallucinations and psychological disturbances, serious physical complications are rare. Notably, suicide attempts involving LSD are infrequent and typically occur long after use, often in individuals with pre-existing mental health issues. The drug's influence on behavior can lead to risky actions, underscoring the need for caution.
Abstract
THE usual oral dose (25μg to 150μg) of lysergic acid diethylamide (LSD) required for a desired psychedelic effect is far below that which causes other serious derangements directly attributable to its pharmacologic activity. Complications of the illicit oral use of the drug, despite larger doses, are also largely limited to its hallucinogenic and psychologic effect. Doses of 20μg/kg of body weight are known to have been taken without a lethal outcome.1To our knowledge no deaths directly related to the use of LSD have been reported, although it has been used unsuccessfully for suicide attempts. (The rare suicide associated with LSD use tends to occur days to months after administration of the drug to a disturbed person.2) Occasionally, a subject under the hallucinogenic influence of the drug will accomplish acts incompatible with life such as attempting unaided flight from the top of a multistory building. The danger of