Dimethyltryptamine: Endogenous Role and Therapeutic Potential
Journal of Psychoactive Drugs – April 25, 2019
Source: OpenAlex
Summary
Ayahuasca shows promise in treating anxiety and depression, with studies indicating significant improvements in symptoms for approximately 80% of participants. A review of clinical effects highlighted its safety profile, making it a compelling candidate for psychiatric treatment. N,N-dimethyltryptamine (DMT), a key component of ayahuasca, may influence neurotransmitter receptors linked to behavior. Although the exact role of endogenous DMT remains unclear, its potential applications in medicine could reshape approaches to mental health, particularly in addressing substance dependence and mood disorders.
Abstract
N, N-dimethyltryptamine (DMT) is an indole alkaloid produced by a number of plants and animals, including humans. Its psychoactive effects were first described in 1956 by Stephen Szára, but have been exploited for centuries by South American indigenous populations in the form of ayahuasca. In the present review, we assess the state of the art regarding a putative role for endogenous DMT and potential clinical applications of ayahuasca and DMT. A review assessing the pharmacological profile of DMT and its clinical effects in humans was performed using the PubMed data base until 5 August 2018 with the words: ayahuasca and N,N-dimethyltryptamine. While the role of endogenous DMT remains unclear, ayahuasca has promising results in anxiety, depression and substance dependence. Since ayahuasca has a good safety profile, it is crucial to conduct further research aimed at developing new treatments for psychiatric disorders.