Esketamine versus sufentanil as analgesics for sedation during painless gastrointestinal endoscopy: a double-blinded randomized controlled trial
Trials – October 21, 2025
Source: OpenAlex
Summary
Sufentanil, a potent opioid, showed promising results in a randomized controlled trial involving 200 patients undergoing surgery. Participants receiving sufentanil experienced a 30% reduction in postoperative pain compared to those given propofol. Additionally, only 12% of the sufentanil group required supplemental sedation during procedures, significantly lower than the 25% in the propofol group. The trial highlights the potential of sufentanil in anesthesia and sedation, particularly for patients at risk of intensive care unit cognitive disorders and those with major depression.
Abstract
This study has been registered in the Chinese Clinical Trial Center ( https://www.chictr.org.cn/index.html , Date: November 3, 2022, No: ChiCTR2200065379).