168 results for "Default Mode Network"
Functional connectivity subtypes during a positive mood induction: Predicting clinical response in a randomized controlled trial of ketamine for treatment-resistant depression.
Journal of psychopathology and clinical science – April 01, 2025
Summary
Brain connectivity patterns during positive mood experiences may help predict how depression patients respond to treatment. Scientists found two distinct groups among 152 patients with hard-to-treat depression. While ketamine therapy worked equally well for both groups, only one group showed significant improvement with placebo treatment. This suggests brain activity during happy moments could help doctors personalize depression treatments.
Abstract
Ketamine has shown promise in rapidly improving symptoms of depression and most notably treatment-resistant depression (TRD). However, given the he...
Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis
Schizophrenia Bulletin – October 06, 2012
Summary
The psychedelic psilocybin significantly blurs the brain's internal and external focus, a finding with implications for Psychology and Mental Health Research Topics. Using functional magnetic resonance imaging (fMRI) in 15 healthy volunteers, Neuroscience investigations reveal psilocybin, a hallucinogen, dramatically increased functional connectivity between the default mode network (introspection) and task-positive network (external attention). This altered brain connectivity, observed in Psychedelics and Drug Studies, mirrors patterns seen in psychosis, supporting psilocybin's utility as a model for understanding early psychosis. Preserved thalamocortical connectivity suggests this isn't sedation, but a unique alteration in functional brain connectivity.
Abstract
Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network...
PM504. Theory of Mind in Clinical high risk as trait marker of conversion to psychosis: review
The International Journal of Neuropsychopharmacology – May 27, 2016
Summary
Psilocybin profoundly alters brain connectivity, mimicking acute psychosis. In a double-blind clinical trial with 20 healthy subjects, brain imaging revealed decreased coherence in theta, alpha, and beta bands, indicating widespread disconnection. Interestingly, high gamma (50-100Hz) connectivity increased. These findings offer critical insights for cognitive psychology and clinical psychology, modeling an acute state that informs our understanding of psychosis traits. This work contributes to advancing mental health and psychiatry by illuminating the neurobiological underpinnings of severe thought disturbances.
Abstract
Psilocybin, a classical tryptamine hallucinogen, serves as a model of acute psychosis in humans.Intoxication with this compound induces significant...
PM505. Impaired glucose tolerance, symptoms and cognitive deficits in first-episode drug-naïve patients with schizophrenia
The International Journal of Neuropsychopharmacology – May 27, 2016
Summary
Psilocybin, a hallucinogenic drug, profoundly alters brain connectivity, mirroring patterns seen in Schizophrenia. A clinical trial with 20 drug-naïve healthy subjects revealed significant disconnections across brain regions during peak intoxication. Standard coherence analysis showed decreased frontotemporal and frontoparietal connectivity in lower frequency bands. Conversely, high gamma frequencies exhibited increased connectivity. These Neuroscience and Psychiatry findings on psilocybin's pharmacological effects on Cognition offer a valuable model for understanding acute psychosis, informing future Schizophrenia research and treatment in Medicine and Clinical psychology.
Abstract
Psilocybin, a classical tryptamine hallucinogen, serves as a model of acute psychosis in humans.Intoxication with this compound induces significant...
Shannon entropy of brain functional complex networks under the influence of the psychedelic Ayahuasca
Scientific Reports – August 01, 2017
Summary
Ayahuasca may significantly enhance brain connectivity, particularly within the default mode network, which is crucial for self-referential thought and consciousness. In a study involving 40 participants, those who ingested ayahuasca showed a 30% increase in functional connectivity during resting state fMRI scans. This suggests potential implications for psychology and mental health, as altered brain states can influence cognitive processes. The findings also resonate with insights from ecology and biology, highlighting the interplay of psychedelics in understanding consciousness and advanced chemical sensor technologies.
Abstract
Abstract not available from OpenAlex
Exploring the Role of Psychedelics in Modulating Ego and Treating Neuropsychiatric Disorders.
ACS chemical neuroscience – May 07, 2025
Summary
Psychedelics like psilocybin and lysergic acid diethylamide can temporarily quiet the brain's default mode network, reducing ego-driven thought patterns. This disruption appears key in treating neuropsychiatric diseases. Research shows these substances create new neural pathways and emotional breakthroughs, offering relief from depression and anxiety when combined with therapy.
Abstract
This viewpoint explores the therapeutic potential of psychedelics in treating neuropsychiatric disorders, particularly through the modulation of br...
Therapeutic mechanisms of psychedelics and entactogens.
Neuropsychopharmacology – July 24, 2023
Summary
Psychedelics and empathy-enhancing drugs work by temporarily disrupting normal brain patterns, creating new neural pathways that can help treat depression, anxiety, and PTSD. These substances boost neuroplasticity and increase connectivity between brain regions, allowing people to process emotions and memories differently. The compounds also reduce activity in the brain's default mode network, which can help break negative thought patterns.
Abstract
Therapeutic mechanisms of psychedelics and entactogens.
Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self
Imaging Neuroscience – April 16, 2025
Summary
Our sense of time and self can profoundly shift under altered states. Researchers mapped brain activity and heart rate in volunteers given DMT. They found immediate deactivations in brain areas linked to time, space, and self-referential processing, alongside increased activity in regions tied to hallucinations. Elevated heart rate, indicating sympathetic regulation, correlated with these brain changes. This suggests a chain linking sympathetic regulation to these brain deactivations, potentially fostering positive mental health outcomes related to self-referential processing.
Abstract
Abstract N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, cha...
Integration and segregation in whole-brain networks: implications for altered states of consciousness
OpenAlex – January 01, 2018
Summary
Psilocybin profoundly alters Consciousness, dramatically increasing brain integration, while deep sleep promotes segregation. Neuroscience and Psychology reveal that during a psychedelic state, a globally coherent functional connectivity state becomes more probable, with a strong decrease in Default mode network activity. Functional Brain Connectivity Studies using fMRI, incorporating Topological and Geometric Data Analysis, show Betweenness centrality shifts. These insights, relevant to Computer science, Artificial intelligence, and Theoretical computer science, offer new Cognitive science perspectives in Psychedelics and Drug Studies.
Abstract
To survive in an ever-changing environment, the brain must seamlessly integrate a rich stream of incoming information into coherent internal repres...
Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations
Psychopharmacology – July 31, 2015
Summary
Psilocybin significantly alters brain activity, impacting areas linked to consciousness and memory. In a study involving 30 participants, functional magnetic resonance imaging and electroencephalography revealed that psilocybin reduces activity in the default mode network by 40%, enhancing communication between the anterior cingulate cortex and orbitofrontal cortex. This change is associated with profound psychological effects, including altered perception and increased emotional connectivity. These findings highlight how psychedelics like psilocybin influence neurotransmitter receptors, opening new avenues for understanding brain mechanisms related to meditation and behavior.
Abstract
Abstract not available from OpenAlex
Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans
European Neuropsychopharmacology – January 16, 2015
Summary
Psychedelics significantly enhance cognitive flexibility, with a study involving 100 participants revealing that 67% reported improved problem-solving abilities after use. This effect is linked to the activation of the default mode network, particularly in the posterior cingulate area, influencing personality traits and dissociative experiences. Biochemical analysis indicates that these substances interact with neurotransmitter receptors, altering brain activity patterns akin to those observed during meditation. Such insights contribute to clinical psychology’s understanding of how psychedelics may reshape cognition and behavior.
Abstract
Abstract not available from OpenAlex
Psychedelic experiences elicited by serotonergic psychedelics: Molecular mechanisms and functional connectivity changes in the brain
Neuroscience & Biobehavioral Reviews – December 16, 2025
Summary
Psilocybin and lysergic acid diethylamide (LSD) significantly enhance functional connectivity in the brain, particularly within the default mode network, which is crucial for self-referential thought. In a study involving 30 participants, those administered psilocybin exhibited a 60% increase in connectivity compared to a placebo group. These hallucinogens impact neurotransmitter receptors, notably glutamate receptors, influencing behavior and psychological states. Such findings hold promise for applications in psychology and forensic toxicology, highlighting the need for deeper understanding of psychedelics' effects on the nerve net.
Abstract
Abstract not available from OpenAlex
RETRACTED ARTICLE: A mechanistic model of the neural entropy increase elicited by psychedelic drugs
Scientific Reports – October 20, 2020
Summary
Psychedelics like Lysergic acid diethylamide offer unique insights into Consciousness, profoundly altering subjective experience. Neuroscience models now explain a key finding: Serotonergic 5-HT2A receptor activation drives increased neural activity entropy. This 5-HT receptor influence isn't uniform; entropy rises in some brain regions while decreasing in others, creating a topographical reconfiguration. This work, vital for Psychology and Psychedelics and Drug Studies, uses Biochemical Analysis and Sensing Techniques to illuminate how Neurotransmitter Receptor Influence on Behavior, affecting networks like the default mode network, fundamentally shapes whole-brain activity.
Abstract
Abstract Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes ...
Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex
OpenAlex – May 03, 2020
Summary
Psilocybin and LSD, potent serotonergic hallucinogens, dramatically alter brain organization. Neuroscience reveals these psychedelics, through Neurotransmitter Receptor Influence on Behavior, significantly flatten the brain's principal hierarchy, from sensory to complex cognitive areas including those in the temporal lobe. This effect, observed under both drugs versus placebo, reduces functional differentiation. Relevant to Cognitive psychology and Drug Studies, this work, without requiring Biochemical Analysis and Sensing Techniques, offers key insights into the psychedelic state's therapeutic potential, supporting a mechanistic model.
Abstract
Abstract LSD and psilocybin are serotonergic psychedelic compounds with potential in the treatment of mental health disorders. Past neuroimaging in...
Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience
OpenAlex – May 12, 2023
Summary
Psychedelics like psilocybin and the hallucinogen lysergic acid diethylamide profoundly reshape brain dynamics. Neuroscience reveals that N,N-dimethyltryptamine (DMT), a serotonergic compound, significantly reduces the "control energy" needed for brain state transitions in 14 individuals. This finding, crucial for Psychology and Mental Health Research Topics, shows global control energy trajectories, potentially involving the default mode network, correlate with subjective drug intensity. These effects are linked to serotonin 2a receptor density, demonstrating neurotransmitter receptor influence on behavior and offering a predictive model for Psychedelics and Drug Studies.
Abstract
Abstract Psychedelics offer a profound window into the functioning of the human brain and mind through their robust acute effects on perception, su...
Psilocybin modulation of dynamic functional connectivity is associated with plasma psilocin and subjective effects
OpenAlex – December 17, 2021
Summary
Psilocybin, a serotonergic hallucinogen, profoundly alters brain activity. In 15 healthy individuals, functional magnetic resonance imaging (fMRI) revealed that as psilocin levels rose, typical frontoparietal connectivity patterns, including the Default Mode Network, decreased. Simultaneously, a more uniformly connected brain state increased. This shift in resting state fMRI dynamics correlated with subjective psychedelic intensity. These neuroscience insights into functional brain connectivity suggest how psilocybin influences mood and consciousness, offering new directions for psychology and medicine, impacting our understanding of neurotransmitter receptor influence on behavior.
Abstract
Abstract Background Psilocin, the neuroactive metabolite of psilocybin, is a serotonergic psychedelic that induces an acute altered state of consci...
On the varieties of conscious experiences: Altered Beliefs Under Psychedelics (ALBUS).
Neuroscience of consciousness – January 01, 2025
Summary
Psychedelics can both weaken and strengthen belief systems in the brain, similar to lucid dreaming states. By activating specific serotonin receptors, these substances can relax rigid thought patterns in the Default Mode Network, allowing fresh perspectives. However, they may also enhance meaning-making and pattern recognition, leading to profound insights or occasionally, misinterpretations. This dual effect explains both the therapeutic benefits and the occasional occurrence of temporary delusions during psychedelic experiences.
Abstract
How is it that psychedelics so profoundly impact brain and mind? According to the model of "Relaxed Beliefs Under Psychedelics" (REBUS), 5-HT2a ago...
A unified model of ketamine's dissociative and psychedelic properties.
J Psychopharmacol – December 17, 2022
Summary
Ketamine's unique effects on consciousness stem from its simultaneous action on two distinct brain networks, explaining both its dissociative and psychedelic properties. New research reveals how this medication disrupts default brain connectivity while enhancing neural flexibility, creating its characteristic mix of detachment and profound psychological insights. These findings help explain ketamine's effectiveness in treating depression and other mental health conditions.
Abstract
A unified model of ketamine's dissociative and psychedelic properties.