Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives.
Clinics (Sao Paulo, Brazil) January 1, 2024 Dongdong Zang, Xuemei Yang, Hao Wang et al. 4 citations
Four compounds derived from (2R,6R;2S,6S)-hydroxynorketamine (HNK) were tested for antidepressant effects in mice. In the forced swimming test, mice given 10 mg of HNK, compound I5, or compound I6 showed significantly less immobility time at 1 hour and 7 days compared to saline controls. Compounds C and D also reduced immobility in a glass cylinder test. In the locomotor sensitization test, compounds C and D increased movement distance on days 7 and 15 relative to day 1. Both compounds induced conditioned place preference, indicating rewarding effects. The results suggest compounds C and D may have some antidepressant activity, while HNK itself produced a rapid but short-lived antidepressant effect within one week.