Department of Neurosurgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen City, Guangdong Province, China; Guangdong Engineering Technological Research Center for Nervous anatomy and Related Clinical Applications, Shenzhen City, Guangdong Province, China.
2 papers in the library · 14 citations · publishing 2024
The Chinese Short-Form Five Facets of Mindfulness Questionnaire (FFMQ-SF) shows good overall fit for measuring mindfulness in nursing students in mainland China, with confirmatory factor analyses supporting a five-factor structure. Composite reliability values ranged from 0.685 to 0.870, and average variance extracted values from 0.426 to 0.627. One-factor models provided the best fit for four of the five subscales. The cross-sectional study included 240 undergraduate nursing students from a Beijing school of nursing who completed the FFMQ-SF and the Depression-Anxiety-Stress Scale. Results suggest the scale is a valid instrument for assessing mindfulness and its relationship with mental health in this population.
Four compounds derived from (2R,6R;2S,6S)-hydroxynorketamine (HNK) were tested for antidepressant effects in mice. In the forced swimming test, mice given 10 mg of HNK, compound I5, or compound I6 showed significantly less immobility time at 1 hour and 7 days compared to saline controls. Compounds C and D also reduced immobility in a glass cylinder test. In the locomotor sensitization test, compounds C and D increased movement distance on days 7 and 15 relative to day 1. Both compounds induced conditioned place preference, indicating rewarding effects. The results suggest compounds C and D may have some antidepressant activity, while HNK itself produced a rapid but short-lived antidepressant effect within one week.