Clinics (Sao Paulo, Brazil)

ISSN 1980-5322

2 papers in the library · 5 citations · publishing 2024-2025

Papers

Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives.

Clinics (Sao Paulo, Brazil) January 1, 2024 Dongdong Zang, Xuemei Yang, Hao Wang et al. 4 citations

Four compounds derived from (2R,6R;2S,6S)-hydroxynorketamine (HNK) were tested for antidepressant effects in mice. In the forced swimming test, mice given 10 mg of HNK, compound I5, or compound I6 showed significantly less immobility time at 1 hour and 7 days compared to saline controls. Compounds C and D also reduced immobility in a glass cylinder test. In the locomotor sensitization test, compounds C and D increased movement distance on days 7 and 15 relative to day 1. Both compounds induced conditioned place preference, indicating rewarding effects. The results suggest compounds C and D may have some antidepressant activity, while HNK itself produced a rapid but short-lived antidepressant effect within one week.

DOI: 10.1016/j.clinsp.2024.100435 Full text Behavioral sensitization test Forced swimming test Antidepressants antidepressant medication Depression medication +3

Role of meditation on the essence of self in the psychological profile, quality of life and lifestyle - a comparative study.

Clinics (Sao Paulo, Brazil) January 1, 2025 Paula Ricci Arantes, Tatiana Caccese Perrotti, Susan Andrews et al. 1 citation

Experienced practitioners of a meditation technique called Meditation on the Essence of Self (Gurusakásha), which uses visualization and mantra from the Indian tantric tradition, show lower perceived stress, higher resilience, greater empathic concern, better quality of life, and a healthier lifestyle profile compared to non-meditators matched for age, gender, and education. The study compared 23 meditation experts with 29 controls and assessed stress, resilience, mood, empathy, quality of life, and lifestyle. The findings suggest that this form of meditation is associated with improved psychological well-being and quality of life.

DOI: 10.1016/j.clinsp.2025.100682 Full text Meditation Mindfulness Empathy Quality of life +4