Innovative disposable pipette extraction for concurrent analysis of fourteen psychoactive substances in drug users' sweat.
Journal of chromatography. A August 16, 2024 Nayna Cândida Gomes, Oscar G Cabrices, Bruno Spinosa De Martinis 12 citations
A new method using disposable DPX-SCX extraction tips and gas chromatography-mass spectrometry can simultaneously detect and quantify 16 psychoactive substances—including amphetamines, cocaine, fentanyl, and several novel psychoactive substances—in sweat samples collected with laboratory-developed patches. Validation showed quantification limits between 2 and 30 ng per patch and linearity from 2 to 1100 ng per patch. When applied to 30 sweat samples from volunteer drug users, the method detected cocaine, MDMA, nicotine, caffeine, and other compounds, with recovery rates of 72.4% to 97.1%. Sweat is a viable, non-invasive biological matrix for monitoring drug use, particularly in rehabilitation settings.