Zotepine, a new neuroleptic, potently inhibits head-twitch induced by L-5-hydroxytryptophan, mescaline, and 2,5-dimethoxy-4-methylamphetamine in mice and rats, similar to haloperidol and the serotonin receptor blocker cyproheptadine. The results indicate zotepine has a potent anti-hallucinogenic effect.
Zotepine, a new neuroleptic, potently inhibits head-twitch induced by L-5-hydroxytryptophan, mescaline, and 2,5-dimethoxy-4-methylamphetamine in mice and rats, similar to haloperidol and the serotonin receptor blocker cyproheptadine. The results indicate that zotepine has a potent anti-hallucinogenic effect.