The Japanese Journal of Pharmacology
January 1, 1983
Tsuneyuki Yamamoto, Naoe Tazoe, Showa Ueki et al.
9 citations
Zotepine, a new neuroleptic, potently inhibits head-twitch induced by L-5-hydroxytryptophan, mescaline, and 2,5-dimethoxy-4-methylamphetamine in mice and rats, similar to haloperidol and the serotonin receptor blocker cyproheptadine. The results indicate zotepine has a potent anti-hallucinogenic effect.
The Japanese Journal of Pharmacology
January 1, 1992
Tsuneyuki Yamamoto, Masuo Ohno, Shin‐ichi Yatsugi et al.
7 citations
In mice, several drugs being tested as potential nootropics reduced the number of head-twitches caused by mescaline (100 mg/kg). Idebenone (32 and 100 mg/kg), minaprine (0.32–10 mg/kg), and nebracetam (100 mg/kg) significantly suppressed this response. Cholinesterase inhibitors—tetrahydroaminoacridine (1 and 10 mg/kg), NIK-247 (10 and 18 mg/kg), and physostigmine (0.32 mg/kg)—also reduced the head-twitches. The findings suggest that activating cholinergic pathways, either directly or indirectly, may help inhibit mescaline-induced head-twitches in this animal model.
Drug and alcohol dependence
April 1, 2024
Yoko Nawata, Tsuyoshi Nishioku, Tsuneyuki Yamamoto et al.
2 citations
Repeated administration of MDMA (10 mg/kg daily for 7 days) to mice impaired their recognition memory during withdrawal, as measured by a novel object recognition task. This impairment was prevented by co-administration of diclofenac, a cyclooxygenase inhibitor. Prostaglandin E2 levels increased in the hippocampus on the first day of withdrawal, but not in the prefrontal cortex or striatum. The findings suggest that activation of the arachidonic acid cascade, particularly in the hippocampus, contributes to recognition memory deficits during MDMA withdrawal. Co-use of cyclooxygenase inhibitors with MDMA may reduce concerns about MDMA-induced memory impairment.
The Japanese Journal of Pharmacology
January 1, 1983
Tsuneyuki Yamamoto, Naoe Tazoe, Showa Ueki et al.
2 citations
Zotepine, a new neuroleptic, potently inhibits head-twitch induced by L-5-hydroxytryptophan, mescaline, and 2,5-dimethoxy-4-methylamphetamine in mice and rats, similar to haloperidol and the serotonin receptor blocker cyproheptadine. The results indicate that zotepine has a potent anti-hallucinogenic effect.
The Japanese Journal of Pharmacology
January 1, 1992
Tsuneyuki Yamamoto, Masuo Ohno, Shin‐ichi Yatsugi et al.
1 citation
In mice, several nootropic candidates reduced head-twitches caused by mescaline. Idebenone, minaprine, and nebracetam significantly lowered the number of mescaline-induced head-twitches. Cholinesterase inhibitors, including tetrahydroaminoacridine, NIK-247, and physostigmine, also suppressed this response. These findings suggest that direct or indirect activation of the cholinergic system may play a role in inhibiting mescaline-induced head-twitches.