In mice, several drugs being tested as potential nootropics reduced the number of head-twitches caused by mescaline (100 mg/kg). Idebenone (32 and 100 mg/kg), minaprine (0.32–10 mg/kg), and nebracetam (100 mg/kg) significantly suppressed this response. Cholinesterase inhibitors—tetrahydroaminoacridine (1 and 10 mg/kg), NIK-247 (10 and 18 mg/kg), and physostigmine (0.32 mg/kg)—also reduced the head-twitches. The findings suggest that activating cholinergic pathways, either directly or indirectly, may help inhibit mescaline-induced head-twitches in this animal model.
In mice, several nootropic candidates reduced head-twitches caused by mescaline. Idebenone, minaprine, and nebracetam significantly lowered the number of mescaline-induced head-twitches. Cholinesterase inhibitors, including tetrahydroaminoacridine, NIK-247, and physostigmine, also suppressed this response. These findings suggest that direct or indirect activation of the cholinergic system may play a role in inhibiting mescaline-induced head-twitches.