Frederic Sampedro

Sant Pau Institute of Biomedical Research (IIB-Sant Pau), Barcelona, Spain.

2 papers in the library · 222 citations · publishing 2017-2022

Papers

Assessing the Psychedelic “After-Glow” in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities

The International Journal of Neuropsychopharmacology May 17, 2017 Frederic Sampedro, Mario de la Fuente Revenga, Marta Valle et al. 205 citations

Ayahuasca, a psychedelic brew, alters brain chemistry and connectivity in ways that may explain its lasting psychological effects. The findings point to glutamate neurotransmission playing a role in how psychedelics work in humans. Neurometabolic changes in the posterior cingulate cortex, a hub of the default mode network, along with increased connectivity between the anterior cingulate cortex and medial temporal lobe structures involved in emotion and memory, likely underlie the post-acute psychological effects of ayahuasca.

DOI: 10.1093/ijnp/pyx036 Full text Ayahuasca Mindfulness Functional connectivity Hallucinogen +4

The Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salvinorin-A.

The international journal of neuropsychopharmacology January 12, 2022 Genís Ona, Frederic Sampedro, Sergio Romero et al. 17 citations

Kappa opioid receptor (KOR) agonists like salvinorin-A produce psychotomimetic effects through largely unknown mechanisms. In a double-blind, crossover, randomized, placebo-controlled study, acute administration of salvinorin-A increased delta and gamma brain waves while decreasing alpha waves, as measured by electroencephalography. Single-photon emission computed tomography revealed significant decreases in regional cerebral blood flow across frontal, temporal, parietal, and occipital cortices, with increases in the medial temporal lobe, amygdala, hippocampal gyrus, and cerebellum. Subjective effects resembled other psychotomimetic drugs but were distinctly dissociative, with no dysphoria reported. KOR agonism by salvinorin-A induces dramatic psychotomimetic effects alongside generalized reductions in cortical blood flow and electrical activity.

DOI: 10.1093/ijnp/pyab063 Full text Kappa opioid receptor Spect Hallucinogens Opioids +11