New psychoactive substances (NPS) appeared in 112 of 1,058 analyzed forensic cases from 2012–2014, with 75 cases in 2014 alone. The overall prevalence of NPS (15.1–17.6%) was similar to that of amphetamine alone (15.1–16.5%). Cathinones made up 88% of the NPS detected, most frequently 3-MMC, α-PVP, and pentedrone. In 35% of cases, a single NPS was the only drug found; two or more NPS appeared in 19% of cases; and most cases (65%) involved NPS alongside conventional drugs such as amphetamines, cannabinoids, cocaine, or benzodiazepines. NPS were often found in drivers' blood, posing a challenge for toxicologists due to limited data on their effects on psychomotor performance.
NBOMe compounds, a new class of psychedelic drugs derived from the 2C family, are ultrapotent and highly selective agonists of serotonin 5-HT2A and 5-HT2C receptors, with over 1000-fold selectivity for 5-HT2A compared to 5-HT1A. Sold in various forms and administered via multiple routes, they have caused numerous clinical intoxications and fatalities since the early 2010s. Adverse effects include hallucinations, agitation, seizures, and sympathomimetic signs like mydriasis and tachycardia. This survey reviews their pharmacology, use patterns, metabolism, and analytical detection methods.