NBOMes–Highly Potent and Toxic Alternatives of LSD
Frontiers in Neuroscience February 26, 2020 Monika Kacela, Piotr Adamowicz, Jolanta B. Zawilska 79 citations
NBOMe compounds, a new class of psychedelic drugs derived from the 2C family, are ultrapotent and highly selective agonists of serotonin 5-HT2A and 5-HT2C receptors, with over 1000-fold selectivity for 5-HT2A compared to 5-HT1A. Sold in various forms and administered via multiple routes, they have caused numerous clinical intoxications and fatalities since the early 2010s. Adverse effects include hallucinations, agitation, seizures, and sympathomimetic signs like mydriasis and tachycardia. This survey reviews their pharmacology, use patterns, metabolism, and analytical detection methods.