Laura Perrella

2 papers in the library · 39 citations · publishing 2011-2014

Papers

Designer psychostimulants in urine by liquid chromatography-tandem mass spectrometry.

Journal of forensic sciences January 1, 2014 Sarah Kerrigan, Ashley Mott, Breanna Jatzlau et al. 20 citations

A new laboratory method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) can detect 15 designer psychostimulants in urine at very low concentrations. The drugs include various 2C-phenethylamines, DOx amphetamines, and 4-MTA. Using solid-phase extraction, analytical recoveries ranged from 64% to 92%, and the limit of detection was 0.5 ng/mL for all drugs except 2C-B (1 ng/mL). The technique was evaluated for recovery, precision, accuracy, linearity, matrix effects, and interferences, enabling simultaneous detection of these substances at sub-ng/mL levels. Many such drugs are not targeted in routine toxicology testing and thus go unreported.

DOI: 10.1111/1556-4029.12306 Full text Amphetamines Designer drugs Forensic science Urine +3

Simultaneous detection of ten psychedelic phenethylamines in urine by gas chromatography-mass spectrometry.

Journal of analytical toxicology September 1, 2011 Sarah Kerrigan, Stephanie Banuelos, Laura Perrella et al. 19 citations

A gas chromatography–mass spectrometry method was developed to detect ten psychedelic phenethylamines (2C-B, 2C-H, 2C-I, 2C-T-2, 2C-T-7, 4-MTA, DOB, DOET, DOI, and DOM) in urine. After solid-phase extraction, limits of detection ranged from 2 to 10 ng/mL, and limits of quantitation were 10 ng/mL or less. Precision at 50 and 500 ng/mL gave coefficients of variation of 0.4–7.9%, and accuracy was 91–116%. Calibration curves were linear up to 1500 ng/mL. No carryover occurred at 5000 ng/mL, and no interferences from related compounds or endogenous bases were observed.

DOI: 10.1093/anatox/35.7.459 Full text Psychedelic drugs Drug testing Forensic toxicology Gc-ms