Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice.
Brain research March 27, 1999 X Yu, S Z Imam, G D Newport et al. 17 citations
In female C57BL/6N mice, methamphetamine caused a rise in body temperature and increased levels of a stress protein (HSP-72) in the caudate nucleus. Ibogaine alone lowered body temperature. When ibogaine was given before methamphetamine, it completely prevented the hyperthermia and reduced HSP-72 expression. These results suggest ibogaine can block methamphetamine-induced brain stress and temperature changes.