G D Newport

2 papers in the library · 46 citations · publishing 1996-1999

Papers

Neuroendocrine and neurochemical effects of acute ibogaine administration: a time course evaluation.

Brain research October 21, 1996 S F Ali, G D Newport, W Slikker et al. 29 citations

A single injection of ibogaine (IBO) rapidly increases the hormones prolactin and corticosterone in adult male rats, with prolactin returning to normal within 60 minutes and corticosterone within 24 hours. IBO also reduces dopamine in the striatum and frontal cortex for up to two hours while raising dopamine metabolites, indicating altered dopamine processing. Some dopamine metabolite levels remain below normal 24 hours later. Serotonin and its metabolite decrease only in the striatum at 60 minutes. These effects may relate to ibogaine's reported ability to help reduce drug craving, but further research is needed.

DOI: 10.1016/0006-8993(96)00734-2 Full text

Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice.

Brain research March 27, 1999 X Yu, S Z Imam, G D Newport et al. 17 citations

In female C57BL/6N mice, methamphetamine caused a rise in body temperature and increased levels of a stress protein (HSP-72) in the caudate nucleus. Ibogaine alone lowered body temperature. When ibogaine was given before methamphetamine, it completely prevented the hyperthermia and reduced HSP-72 expression. These results suggest ibogaine can block methamphetamine-induced brain stress and temperature changes.

DOI: 10.1016/s0006-8993(99)01154-3 Full text Ibogaine: ibogaine This compound Methamphetamine: methamphetamine Counteract methamphetamine's impact +4