Department of Critical Care Medicine, Wuxi Medical Center, Wuxi People's Hospital, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, Wuxi City, China.
2 papers in the library · 140 citations · publishing 2020-2025
General anesthesia induced by ketamine or sevoflurane disrupts iron metabolism, causing iron overload in hippocampal neurons and brain tissue. This iron overload triggers ferroptosis, a form of iron-dependent cell death, leading to cognitive deficits in young rats and aged mice. The iron chelator deferiprone reduces mitochondrial dysfunction, ferroptosis, and cognitive impairment. The mechanism involves NMDAR-RASD1 signaling activating DMT1, which mediates iron uptake. Disturbed iron metabolism may contribute to anesthesia-related neurotoxicity and cognitive decline.
A mindfulness-based support program for intensive care unit (ICU) nurses who experienced adverse events reduced adverse event incidence by 34% and improved sleep quality and second victim-related distress. Nurses who received the program had better Pittsburgh sleep quality index scores (decreasing from 12.94 to 9.32) compared to a control group receiving routine support (12.76 to 10.72), and lower scores on the second victim experience and support tool (76.18 vs. 91.52). The program effectively alleviates psychological distress and improves support for ICU nurses affected by adverse events.