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Eyal Kurzbaum

Water Science Department, Tel-Hai College, Upper Galilee 1220800, Israel.

3 papers in the library · 11 citations · publishing 2025-2026

Papers

Exploring Psilocybe cubensis Strains: Cultivation Techniques, Psychoactive Compounds, Genetics and Research Gaps

Journal of Fungi January 28, 2025 Eyal Kurzbaum, Tomáš Páleníček, Amiel Shrchaton et al. 11 citations

The psychoactive mushroom Psilocybe cubensis, known for its historical and modern therapeutic roles, shows substantial variability in its psychoactive compounds, psilocybin and psilocin, due to genetic diversity, strain differences, and environmental factors. Advances in cultivation, such as submerged fermentation of mycelium, and improved analytical methods now allow more precise compound quantification and extraction. Despite nearly four decades of regulatory restrictions limiting scientific information, recent genetic and biochemical studies are beginning to reveal insights into its therapeutic potential. The review identifies key knowledge gaps and suggests future research directions to improve cultivation, document strain diversity, and address regulatory and therapeutic uses.

DOI: 10.3390/jof11020099 Psilocybin Biology Biotechnology Documentation

Surprising Variability in Tryptamine Profiles of Psilocybe cubensis Fruiting Bodies: Inter- and Intra-Strain Differences Across 14 Strains Cultivated Under Controlled Conditions

Journal of Fungi July 2, 2026 Amiel Sharchaton, Shilat Parsha, Sara P. Azerrad et al.

Even when grown under identical conditions, different strains of the same mushroom species, Psilocybe cubensis, vary dramatically in their psychedelic compound content. Total tryptamine concentrations ranged more than 7.8-fold across 14 strains, from 2.62 to 20.65 mg per gram of dried mushroom. Psilocybin was always the most abundant compound. Individual mushrooms from the same strain also showed substantial variation, with psilocybin levels differing by 12.81% to 23.39% between fruiting bodies. This biochemical variability, both between strains and within a single strain, makes it difficult to standardize whole mushroom preparations for research or therapeutic use, emphasizing the need for careful strain selection, chemical profiling, and precise dosing.

DOI: 10.3390/jof12070486 Psilocybin Tryptamine Mushroom Strain injury +3