Exploring Psilocybe cubensis Strains: Cultivation Techniques, Psychoactive Compounds, Genetics and Research Gaps
Journal of Fungi January 28, 2025 Eyal Kurzbaum, Tomáš Páleníček, Amiel Shrchaton et al. 11 citations
The psychoactive mushroom Psilocybe cubensis, known for its historical and modern therapeutic roles, shows substantial variability in its psychoactive compounds, psilocybin and psilocin, due to genetic diversity, strain differences, and environmental factors. Advances in cultivation, such as submerged fermentation of mycelium, and improved analytical methods now allow more precise compound quantification and extraction. Despite nearly four decades of regulatory restrictions limiting scientific information, recent genetic and biochemical studies are beginning to reveal insights into its therapeutic potential. The review identifies key knowledge gaps and suggests future research directions to improve cultivation, document strain diversity, and address regulatory and therapeutic uses.