Journal of Neuroscience
March 12, 2014
Aaron Kucyi, Massieh Moayedi, Irit Weissman‐fogel et al.
390 citations
In patients with chronic pain, rumination—repetitive focus on discomfort—is linked to altered functional connectivity in the brain's default mode network. In a study of 17 patients with temporomandibular disorder and 17 matched healthy controls, those with chronic pain showed enhanced connectivity between the medial prefrontal cortex and other default mode network regions, including the posterior cingulate cortex and precuneus. Among patients, greater rumination about pain correlated with stronger connectivity between the medial prefrontal cortex and the posterior cingulate cortex, precuneus, retrosplenial cortex, medial thalamus, and periaqueductal gray. These results suggest that communication within the default mode network and with the descending pain modulatory system underlies the degree of rumination about chronic pain.
Human brain mapping
January 1, 2025
Isaac N Treves, Aaron Kucyi, Madelynn Park et al.
8 citations
Trait mindfulness—the tendency to attend to present experience non-judgmentally—is linked to better mental health, but its neural basis remains unclear. In the largest resting-state fMRI study of trait mindfulness to date, involving 367 meditation-naïve adults across three sites, no connections predicted overall trait mindfulness. However, neural models for two subscales, Acting with Awareness and Non-judging, were identified. Positive networks for these subscales involved distinct fronto-parietal and default-mode networks, while negative networks overlapped across subscales and included somatomotor, visual, and default-mode regions. Only negative networks generalized to predict subscale scores in some out-of-sample tests. Predictions negatively correlated with a mind-wandering model. The findings provide preliminary evidence for generalizable connectivity models of mindfulness facets, but incomplete generalization across sites and model overlap highlight the challenge of identifying robust brain markers.
bioRxiv Preprint Server
January 20, 2024
Aaron Kucyi, Nathan Anderson, Tiara Bounyarith et al.
2 citations
preprint
Mind-wandering, a common daily mental activity, varies uniquely from person to person. In three individuals who each reported hundreds of mind-wandering episodes during multiple fMRI sessions, reliable links between mind-wandering and default mode network (DMN) activation emerged when brain networks were analyzed within each person. However, the timing of spontaneous DMN activity relative to subjective reports, and the broader networks activated or deactivated during mind-wandering, differed across individuals. Whole-brain connectivity patterns that predicted mind-wandering within an individual did not fully generalize to others, and predictive models from larger datasets largely failed when applied to these densely-sampled individuals. This work demonstrates both conserved and variable neural representations of mind-wandering, highlighting the value of personalized approaches.