Journal of psychoactive drugs
January 1, 2019
Ilana Berlowitz, Heinrich Walt, Christian Ghasarian et al.
70 citations
An integrative treatment program combining Amazonian medicine with psychotherapy significantly reduced substance use disorder symptoms in male patients. Among 36 participants who completed the program, addiction severity for drug and alcohol use, psychiatric status, social and familial relationships, emotional distress, and substance craving all decreased substantially. Quality of life also increased markedly. Nearly all participants were dependent on multiple substances, primarily cannabis, alcohol, and cocaine-related drugs. These preliminary results suggest the approach may offer new therapeutic options for substance use disorders.
Journal of ethnopharmacology
March 25, 2022
Ilana Berlowitz, David M O'Shaughnessy, Michael Heinrich et al.
26 citations
The Peruvian-Amazonian dieta is a retreat-like intervention involving lengthy social, behavioral, and alimentary restrictions while ingesting specially prepared plant substances, many of which are psychoactive. Based on interviews with 16 healers from Ucayali, San Martín, and Loreto provinces, the method is described as transformative, with multifaceted applications for treatment, prevention, and training. Benefits are attributed to teacher plants, dietary conditions, and the healer's skill. A detailed risk assessment revealed sophisticated safety measures. The dieta is a central therapeutic concept and a unique method for using psychoactive plants, warranting inclusion in current psychedelic research.
Frontiers in pharmacology
January 1, 2023
Klemens Egger, Frederik Gudmundsen, Naja Støckel Jessen et al.
17 citations
Co-administration of harmine with DMT in rats increased brain DMT levels by inhibiting its metabolism to indole-3-acetic acid, yet no significant occupancy of serotonin 5-HT2A receptors by DMT was detected, even at brain DMT concentrations up to 11.3 µM. Low doses of DMT and/or harmine did not significantly alter brain glucose metabolism as measured by [18F]FDG-PET. These preliminary findings suggest that the role of MAO-A inhibition in potentiating DMT's psychedelic effects may be more complex than previously assumed, and further dose-response studies are needed.
Plants
January 11, 2023
Ilana Berlowitz, Ernesto García Torres, Caroline Maake et al.
14 citations
In the Peruvian Amazon, Nicotiana rustica (mapacho) is traditionally ingested as a liquid medicine for mental health treatment, contrasting with harmful global tobacco use. A 37-year-old woman with mood, anxiety, attention deficit, and a chronic somatic condition participated in a weeklong retreat led by a traditional healer, involving ritual tobacco ingestion. Experience-sampling during treatment and symptom assessments before and after indicated clinically relevant improvements in well-being. This case study documents the therapeutic process and suggests potential benefits of traditional tobacco use, aligning with renewed scientific interest in psychoactive plants for therapy.
PLOS global public health
January 1, 2025
Ilana Berlowitz, Maria Amalia Pesantes, Cynthia Cárdenas Palacios et al.
6 citations
Indigenous-Amazonian medicine is an intricate medical system built on a sophisticated understanding of health, illness, and treatment. Traditional healers describe multifactorial causes of illness, complex interactions between material and spiritual aspects of body and nature, and treatments that often involve carefully designed applications of 'teacher plants'. Healers view traditional and biomedical systems as complementary, but identify lack of recognition as a primary barrier to collaboration. Preconceptions, stigma, and insufficient research impede countries from meeting Indigenous health needs and perpetuate inequalities. The findings highlight Amazonian healers' unique expertise with psychoactive plants, offering lessons for the revival of psychedelic-assisted therapies.
Health education & behavior : the official publication of the Society for Public Health Education
December 1, 2024
Ilana Berlowitz, Ernesto García Torres, Juan Celidonio Ruiz Macedo et al.
3 citations
Indigenous healers in the Peruvian Amazon use tobacco therapeutically, but this practice has been largely ignored by clinical research. A pilot field study assessed 27 patients before and after a weeklong treatment by a traditional healer specialized in tobacco. Validated self-report scales showed significant reductions in anxiety, depression, perceived stress, and general symptom indicators. Patients reported initial physical discomfort followed by psychologically or spiritually significant insights. The findings suggest a sophisticated therapeutic approach based on Indigenous knowledge that warrants further investigation, contributing to research on therapeutic uses of psychoactive plants.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
June 1, 2026
Klemens Egger, Robert Bozsak, Helena D Aicher et al.
A psychedelic dose of DMT combined with harmine (mimicking ayahuasca) globally increased cerebral glucose metabolism by 12.5% in 14 healthy males, as measured by FDG-PET scans during peak drug effects. Widespread cortical increases appeared in higher-order brain networks. Global glucose metabolism correlated positively with harmine plasma levels but not with DMT levels or subjective intensity. This recapitulates a classic finding for psilocybin, suggesting a potential metabolic signature of the psychedelic state.
Psychology of Consciousness Theory Research and Practice
May 11, 2026
Kush V. Bhatt, Adam W. Hanley, Chantal Martin-Soelch et al.
Mindfulness-based interventions reduce chronic pain, and a secondary analysis of two randomized controlled trials (480 patients on long-term opioid therapy) suggests that nondual awareness—a state of attenuated self-other distinction—partly explains this effect. Participants in an 8-week mindfulness program (MORE) showed significantly lower pain severity and interference than a supportive therapy control group, along with greater increases in nondual awareness. Path analyses indicated that gains in nondual awareness mediated the reductions in pain severity and interference, and nondual awareness was a stronger mediator than the mindfulness facet of nonreactivity. The findings link mindfulness-induced nondual awareness to chronic pain relief, and future work should explore neurobiological mechanisms and other interventions that foster nondual awareness.