Journal of psychiatric research
May 1, 2022
Timothy D Brewerton, Julie B Wang, Adele Lafrance et al.
81 citations
Among 89 individuals with severe PTSD enrolled in a placebo-controlled trial of MDMA-assisted therapy, 15% had eating disorder symptoms in the clinical range and 31.5% in the high-risk range at baseline, despite no active purging or low weight. After treatment, participants who received MDMA-assisted therapy showed significantly greater reductions in eating disorder symptoms compared to those who received placebo, especially among women with elevated baseline scores. The findings suggest that eating disorder psychopathology is common in severe PTSD and that MDMA-assisted therapy may reduce these co-occurring symptoms.
Eating and weight disorders : EWD
April 1, 2020
Marika Renelli, Jenna Fletcher, Kenneth W Tupper et al.
76 citations
Ayahuasca, a traditional Amazonian medicine, is being studied for mental health treatment. In this qualitative study, 13 people previously diagnosed with an eating disorder described their experiences with ceremonial ayahuasca and conventional treatment. Thematic analysis of interviews revealed that ayahuasca was associated with rapid reductions in eating disorder thoughts and symptoms, helped heal the perceived root of the disorder, processed painful feelings and memories, fostered self-love and self-acceptance, and catalyzed spiritual healing. The findings suggest ayahuasca may have potential as an adjunctive therapeutic tool, warranting further controlled clinical trials.
Journal of humanistic psychology
October 9, 2021
Adele Lafrance, E. Strahan, Brian M. Bird et al.
40 citations
A survey of 159 people who had used classic psychedelics found that such use was linked to greater spirituality, which in turn predicted better emotion regulation, and ultimately lower levels of anxiety, depressed mood, and disordered eating. The results suggest a pathway through which psychedelic use may improve mental health by first enhancing spirituality and then improving the ability to manage emotions. The findings add to evidence that cultivating spirituality and emotion regulation may be healing mechanisms, though the study does not establish causation.
Medical hypotheses
January 1, 2021
Timothy D Brewerton, Adele Lafrance, Michael C Mithoefer
28 citations
Eating disorders remain difficult to treat, especially when accompanied by posttraumatic stress disorder. MDMA-assisted psychotherapy for treatment-resistant PTSD shows promise, with two-thirds of participants achieving full remission at one year or more follow-up. The authors hypothesize this therapy will be effective for both eating disorder and PTSD symptoms in people with both conditions. MDMA's effects—reduced fear, enhanced wellbeing, increased sociability, reduced self-criticism, increased compassion, interpersonal trust, and alert consciousness—may counteract avoidance and hyperarousal in therapy. Other features like body image distortion, cognitive rigidity, and socio-emotional difficulties may also improve. Personal accounts describe benefit, but risks and challenges are noted.
Journal of eating disorders
September 30, 2024
Adele Lafrance, Meg J Spriggs, Natalie Gukasyan et al.
8 citations
Psychedelic medicine, including psychedelic-assisted therapy (PAT), may offer a valuable adjunct to existing treatments for eating disorders, particularly anorexia nervosa, by addressing underlying psychological and transpersonal factors and improving treatment engagement. Preliminary findings from multiple studies suggest promise, though risks remain. This commentary, informed by lived experience and authors' field experience, provides a rationale and multi-dimensional perspective for applying these models as they become more accessible in naturalistic, research, and clinical settings.
Journal of psychoactive drugs
January 1, 2023
Meris Williams, Annie Kingston Miller, Anja Loizaga-Velder et al.
8 citations
Ayahuasca, a psychedelic plant medicine from the Amazon, is being studied as a potential novel intervention for eating disorders (EDs), which have high mortality, chronicity, and treatment drop-out rates. Interviews with 15 ayahuasca ceremony leaders revealed two main categories of perspectives. Leaders conceptualized EDs as symptomatic of underlying concerns, serving a function and affecting health across multiple domains. They described ayahuasca's potential therapeutic mechanisms as facilitating energetic healing, helping identify and process the root of the ED, promoting holistic healing, and enhancing relationships. From ceremony leaders' views, ceremonial ayahuasca may offer a useful complementary intervention for EDs.
Eating disorders
January 1, 2024
Meris Williams, Annie Kingston Miller, Adele Lafrance
6 citations
Ayahuasca, a psychedelic plant medicine from Indigenous Amazonian communities, is being explored as a novel treatment for eating disorders (EDs), which are difficult to resolve. Aspects of ceremonial ayahuasca use, such as purging and dietary restrictions, resemble ED behaviors, raising concerns about its suitability. Interviews with 15 ayahuasca ceremony leaders, mostly from the West/Global North, revealed categories including screening for EDs, purging and dietary restrictions, potential risks, and complementarity with conventional ED treatment. The findings suggest careful screening and extra support can promote safe ceremony experiences. More research is needed on purging and preparatory diets. The ED field could collaborate with ayahuasca ceremony leaders in a decolonizing, bidirectional bridging between Western and Indigenous healing paradigms.
Child and adolescent psychiatry and mental health
June 4, 2025
Sarah Forsberg, Amanda E Downey, Lindsey D Bruett et al.
5 citations
Psychedelic-assisted therapy is gaining interest for treating mental health conditions in adolescents, but safe and effective delivery requires careful consideration of caregiver involvement. Caregivers are essential in adolescent mental health treatment, supporting recovery and disrupting illness-maintaining patterns, while also needing resources to manage caregiving challenges. This review synthesizes evidence from adolescent mental health treatments, PAT best practices, and family systems theory to propose a framework for integrating caregivers into adolescent PAT. The family system is a critical setting that may shape PAT efficacy, analogous to the therapeutic setting (set and setting). Recommendations are provided for incorporating caregivers into PAT protocols to maximize safety and efficacy.
SSRN Electronic Journal
Robin Sandell, Adele Lafrance, Olivia Gosseries et al.
In three people with incomplete spinal cord injuries who self-medicated with psilocybin, improvements in motor function, muscle activation, and strength were reported. One person with a C4–C5 injury noted better gait automaticity; another with a T7 injury regained activation of a previously non-responsive hamstring muscle; a third with a T12 injury experienced rapid strength gains and enhanced proprioceptive awareness. All three reported psychological benefits such as increased wellbeing, motivation for recovery, and improved adjustment. Benefits appeared greatest in partially innervated muscles and diminished after stopping psilocybin. Temporary spasticity was the only adverse effect. The authors suggest psilocybin may enhance recovery by amplifying existing neural pathways and call for controlled clinical trials.