Unraveling the metabolomic profile and acute toxicity of ethanolic extract from Mimosa tenuiflora (Willd.) Poir. root bark.
Toxicon : official journal of the International Society on Toxinology October 1, 2024 Renato Pinto De Sousa, Carlos Mario Freitas De Oliveira, Rita de Cassia De Lima Sousa et al. 6 citations
An ethanolic extract of Mimosa tenuiflora root bark, used in a psychedelic drink called 'jurema wine' in Indigenous Brazilian rituals, was analyzed for chemical composition and acute oral toxicity. Thirteen compounds were identified, including proanthocyanidins, alkaloids, a flavonol, and a dihydrochalcone. In female Swiss mice, single oral doses of 300 and 2000 mg/kg caused no deaths, no changes in food intake or body weight, and the lethal dose 50 (LD50) exceeded 2000 mg/kg, placing the extract in GHS category 5. However, both doses significantly altered relative kidney weights, hematological and biochemical parameters, and caused histopathological changes in the heart, liver, and kidneys, indicating acute oral toxicity.