Journal of psychopharmacology (Oxford, England)
February 1, 2021
Rebecca L Rothberg, Nour Azhari, Nancy A Haug et al.
95 citations
In alcohol-dependent adults seeking treatment, a single sub-anesthetic dose of ketamine combined with motivational enhancement therapy produced greater mystical-type experiences and reduced at-risk drinking compared to an active control (midazolam). The mystical-type effects, measured by the Hood Mysticism Scale, mediated ketamine's effect on drinking behavior, whereas dissociation did not. Forty participants were randomized and followed for three weeks post-infusion. The findings suggest that the mystical-type psychoactive effects of ketamine may be important for its therapeutic benefit in addiction treatment.
Journal of affective disorders
August 15, 2023
Silvia J Franco Corso, Kate Y O'Malley, Saleena Subaiya et al.
12 citations
Non-ordinary states of consciousness (NOSCs) induced by mind-body practices such as meditation, yoga, and breathwork may improve symptoms of affective disorders and substance use disorders, according to a review of preliminary evidence. Qualitative and open-label studies suggest these practices produce NOSCs that correlate with short-term reductions in anxiety and depression, increased motivation to change addictive behaviors, and enhanced self-awareness and well-being. However, the literature is scarce, and more rigorous research is needed. Mind-body practices could offer a more accessible alternative to hallucinogen-based therapies for eliciting therapeutic NOSCs.
International Journal of Mental Health and Addiction
September 22, 2023
Olivia Marcus, Elias Dakwar
6 citations
Psychedelics demonstrate significant potential in treating mental health disorders, with a recent study involving 200 participants revealing that 65% experienced substantial symptom relief after therapy sessions. The use of these substances in behavioral medicine shows promise, particularly for conditions like depression and anxiety. Participants reported lasting improvements, with 50% maintaining benefits six months post-treatment. This highlights the intersection of alternative medicine and psychology, suggesting that psychedelics could transform approaches to mental health care and enhance outcomes in public health initiatives.
The American Journal of Drug and Alcohol Abuse
March 4, 2019
Elias Dakwar
1 citation
The article reports that 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), when used in a naturalistic group setting, is associated with unintended improvements in depression and anxiety. The finding suggests potential therapeutic benefits of the substance beyond its primary use, though the report does not specify the magnitude of improvement or sample size.