Intravenous DMT in rats caused dose-dependent increases in serotonin and dopamine in the medial prefrontal and somatosensory cortices, along with changes in brain wave patterns: reduced theta and low gamma power, increased delta, medium gamma, and high gamma power, and altered functional connectivity. All doses produced head twitch responses, most after the low dose. For the first time, endogenous DMT was measured in these cortical sites at levels comparable to serotonin and dopamine, suggesting a physiological role for the compound. The findings point to shared mechanisms with other psychedelics and support DMT's potential for treating psychiatric disorders.
Shamanic journeying, an ancient spiritual practice, produces dynamic changes in heart function measurable through heart rate variability (HRV). In a single subject, drumming initiation decreased heart rate and increased HRV measures, while shapeshifting increased heart rate and certain HRV indicators. Qigong meditation also increased HRV measures, with greater changes in some metrics than drumming initiation. These findings suggest shamanic journeying involves widespread cardiac and physiological changes that can be tracked visually and via ultra-short-term HRV.