The Yale Manual for Psilocybin-Assisted Therapy of Depression offers researchers and therapists a detailed guide on methods, structure, and considerations for using psychedelic-assisted therapy to treat Major Depressive Disorder. It specifically demonstrates how Acceptance and Commitment Therapy (ACT) can serve as a therapeutic framework for psilocybin-assisted depression treatment.
Psilocybin-assisted therapy improves psychological flexibility, mindfulness, and values-congruent living in people with moderate to severe major depressive disorder, and these improvements are strongly linked to reductions in depression severity. In an exploratory placebo-controlled study, participants received placebo then psilocybin (0.3 mg/kg) four weeks later, with dosing sessions embedded in Acceptance and Commitment Therapy. Psychological flexibility, several facets of mindfulness, and values-congruent living significantly improved after psilocybin and were maintained through week 16. The findings suggest that increasing psychological flexibility may be a key mechanism underlying psilocybin's therapeutic effects.
This document is the French translation of the Yale Manual for Psilocybin-Assisted Therapy of Depression. It provides researchers and therapists with methods, structure, and considerations for using psychedelic-assisted therapy to treat major depressive disorder. Specifically, the manual illustrates how Acceptance and Commitment Therapy (ACT) can serve as the therapeutic framework for psilocybin-assisted depression treatment.